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INVESTIGACION
- Pablo Simón Gaete Pauchard (PhD in Physiological Sciences)
- Molecular regulation of the opening dynamics of the pannexin-1-formed channel in endothelial cells: The response triggered by CGRP.
- Pannexin-1 (Panx-1) is a membrane protein that form non-selective channels. In the cardiovascular system, Panx-1 is thought to play a physiological role controlling vasomotor
- tone and blood pressure. Interestingly, recent evidence shows that prolonged activation of
Panx-1-formed channels in the endothelium of resistance arteries in response to the
- calcitonin gene-related peptide (CGRP) leads to vascular dysfunction. Notably, the post-translational modifications (PTMs) and the signaling environment that governs the opening of pannexin-1-
- formed channels are unknown. Then, my research focuses on: 1) To determine the signaling mechanism that controls the activation of Panx-1 induced by CGRP in endothelial cells,
- 2) to assess the structural and functional role of PTMs of panx-1 generated by CGRP and 3) to determine whether CGRP receptor forms signaling microdomains with Panx-1 in endothelial cells.
PROYECTOS
- Programa: FONDECYT POSTDOCTORADO
- Nº de Proyecto: 3160348
- Título: Molecular regulation of the opening dynamics of the pannexin-1-formed channel in endothelial cells: The response triggered by CGRP
- Año de Inicio: 2015
- Año de Término: 2018
PUBLICACIONES RECIENTES
- "Functional role of connexins and pannexins in the interaction between vascular and nervous system". Gaete PS, Lillo MA, Figueroa XF. Journal of Cellular Physiology.
- 2014 Oct;229(10):1336-45.
- "Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels". Figueroa XF, Lillo MA, Gaete PS, Riquelme MA, Sáez JC.
- Neuropharmacology. 2013 Dec;75:471-8.
- "Ca2+-activated K+ channels of small and intermediate conductance control eNOS activation through NAD(P)H oxidase" Pablo S. Gaete, Mauricio A. Lillo, Nicolás M. Ardiles,
- Francisco R. Pérez and Xavier F. Figueroa. Free Radical Biology & Medicine, 2012, 1;52(5):860-70.
Capítulo de libro:
- "Control and coordination of vasomotor tone in the microcirculation" Mauricio A. Lillo, Francisco R. Pérez, Mariela Puebla, Pablo S. Gaete and Xavier F. Figueroa.
- The Cardiovascular System - Physiology, Diagnostics and Clinical Implications, David C. Gaze (Ed.), ISBN: 978-953-51-0534-3, InTech Publisher. 2011.
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