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      INVESTIGACION

  1. I am a postdoctoral researcher, my investigation is focused on correlating the molecular architecture (stoichiometry and arrangement of subunits within heteromeric protein) with the
  2. function of the membrane protein by using atomic force microscopy (AFM), high-speed AFM and patch clamp techniques. My model protein is heteromeric conexin Cx26/Cx30
  3. hemichannels.
  4. In addition I want to determine if mutations in Cx26 modify the molecular architecture of the heteromeric hemichannels and whether this change affects their function. This is relevant
  5. because Cx26 mutations have been associated with moderate and severe diseases in humans such as deafness and keratitis ichthyosis deafness syndrome.

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