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INVESTIGACION
- I am a postdoctoral researcher, my investigation is focused on correlating the molecular architecture (stoichiometry and arrangement of subunits within heteromeric protein) with the
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- function of the membrane protein by using atomic force microscopy (AFM), high-speed AFM and patch clamp techniques. My model protein is heteromeric conexin Cx26/Cx30
- hemichannels.
- In addition I want to determine if mutations in Cx26 modify the molecular architecture of the heteromeric hemichannels and whether this change affects their function. This is relevant
- because Cx26 mutations have been associated with moderate and severe diseases in humans such as deafness and keratitis ichthyosis deafness syndrome.
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